Thoracic sequelae and complications of tuberculosis. 8. Post-primary tuberculosis , also known as reactivation tuberculosis or secondary tuberculosis usually occurs during the two years following the initial infection. In the vast majority of cases, they develop in the posterior segments of the upper lobes (85%)1,7. Radiology. 1993;186 (3): 653-60. Post-primary infections are far more likely to cavitate than primary infections and are seen in 20-45% of cases. Only in 5% of patients, usually those with impaired immunity, go on to have progressive primary tuberculosis. 2014; 18(2):128-33 (ISSN: 1815-7920) Hicks A; Muthukumarasamy S; Maxwell D; Howlett D. The chest radiograph (CXR) is a key initial tool in the diagnosis of many lung conditions, including pulmonary tuberculosis (TB). We review potential acute and chronic complications of TB disease and current management approaches. (1) Nunes C. However, lesions may appear anywhere in the lungs. September... © 2003-2020 ESR - European Society of Radiology, https://dx.doi.org/10.1594/ecr2011/C-1671. Lippincott Williams & Wilkins. 1 Burman WJ, Goldberg S, Johnson JL, et al. Patients with AIDS demonstrate altered patterns of infection depending on their CD4 count. A variety of thoracic sequelae and complications from pulmonary TB may occur and may involve the lungs, airways, vessels, mediastinum, pleura, or chest wall [47, 68–71] (Appendix 1, Figs. Int J Tuberc Lung Dis. It is also important to be aware of historical treatments for pulmonary tuberculosis that may still be seen incidentally radiographically nowadays, such as plombage, thoracoplasty, or oleothorax. A total of 148 patients with massive hemoptysis due to pulmonary tuberculosis … Although implants are seen throughout the body, the lungs are usually the easiest location to image. The primary infection is usually asymptomatic (the majority of cases), although a small number go on to have symptomatic hematological dissemination which may result in miliary tuberculosis. The primary infection is usually asymptomatic (the majority of cases), although a small number go on to have symptomatic hematological dissemination which may result in miliary tuberculosis. These sequelae may involve the parenquima, airway, mediastinum, pleura, chest wall, or any combination of these structures. Shields TW, LoCicero J, Ponn RB. Lippincott Williams & Wilkins. As the host mounts an appropriate immune response both the pulmonary and nodal disease resolve. Kazerooni EA, Gross BH. Frequent radiologic findings of pulmonary tuberculosis in infants are mediastinal or hilar lymphadenopathy with central necrosis and air-space consolidations, especially masslike consolidations with low-attenuation areas or cavities within the consolidation. In symptomatic patients, constitutional symptoms are prominent with fever, malaise, and weight loss. Radiological studies may show a fibrotic, contracted lung; hilar elevation, lower … et al.Tuberculosis incidence in Portugal: spatiotemporal clustering. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. Sequelae of previous tuberculosis that is now inactive manifest characteristically as fibronodular opacities in the apical and upper lung zones. PTB infection often leaves long term sequelae of infection, particularly granulomatous nodules, cavitation, and fibrosis; distinguishing dormant disease from reactivation is … (4)Yeon Joo Jeong et al. Therefore, When CD4 count drops to below 350 cells/mm3 pulmonary manifestations appear similar to run-of-the-mill post-primary infections (see below). Complications of pulmonary tuberculosis. Occasionally these nodes may be large enough to compress adjacent airways resulting in distal atelectasis 1. Some patients may show a paradoxical reaction on imaging. Pulmonary tuberculosis: CT findings-early active disease and sequential change with antituberculous therapy. Miliary deposits appear as 1-3 mm diameter nodules, which are uniform in size and uniformly distributed 1-2. contrary to the evolution of most infectious diseases, In accordance with the virulence of the organism and the defenses of the host, tuberculosis can occur in the lungs and in extrapulmonary organs. 1.Those resulting from the disease Poey C, Verhaegen F, Giron J et-al. Imaging of pulmonary infections. Tuberculomas account for only 5% of cases of post-primary TB and appear as a well defined rounded mass typically located in the upper lobes. Lee JJ, Chong PY, Lin CB et-al. illustrating a variety of sequelae lesions duo to Pulmonary Tuberculosis. Figure 1: gross pathology - cavitating pulmonary tuberculosis, Figure 2: gross pathology - miliary tuberculosis, Case 4: primary progressive pulmonary tuberculosis, Case 18: post-primary pulmonary tuberculosis, Case 30: post primary pulmonary tuberculosis, Case 33: endotracheal spread with tree in bud appearance, Upper zone changes in ankylosing spondylitis, pulmonary Mycobacterium avium complex (MAC) infections, differential of miliary pulmonary opacities, differential of alveolar pulmonary consolidation, doi:10.1148/radiographics.21.4.g01jl06839. Pulmonary tuberculosis: up-to-date imaging and management. Am J Respir Crit Care Med . Complications. Only in 5% of patients, usually those with impaired immunity, go on to have progressive primary tuberculosis. 3. Any patient with tuberculosis should be considered infective until sputum assessment is performed, and patients should be placed in respiratory isolation. Late sequelae of tuberculous pleuritis include chronic persistent pleural effusion, empyema necessitatis, bronchopleural fistula, pleural malignancy, fibrothorax and pleural thickening which may be associated with extensive calcification. Extensive pulmonary parenchymal destruction may occur in primary or re-activation TB. Isolated tracheal infection by tuberculosis is rare but reported and typically results in irregular circumferential mural thickening. Conventional radiography, Thorax, Respiratory system, Lung. the colonization of cavities by fungus, e.g. 2008;191 (3): 834-44. To explore the strategy and curative effect of emergency transcatheter arterial embolization (ETAE) in patients with massive hemoptysis due to pulmonary tuberculosis and tuberculosis sequelae. General thoracic surgery. Collins J, Stern EJ. The development of an air-fluid level implies communication with the airway, and thus the possibility of contagion. Since one of the commonest sites of primary infection is the lung, tuberculosis, in any other part of the human body, may be considered a complication of pulmonary tuberculosis. The clinical manifestations and evaluation of pulmonary TB will be reviewed here. 2006 Aug 1. Patients with post-primary pulmonary tuberculosis are often asymptomatic or have only minor symptoms, such as a chronic dry cough. Sequelae of previous tuberculosis that is now inactive manifest characteristically as fibronodular opacities in the apical and upper lung zones. Generally, imaging workup starts with plain chest radiography. Imaging of Chest Wall Disorders. The tests also allow prediction of the patients at risk of surgical complications and death. Check for errors and try again. with the disease being one of the major causes of illness and death. Having in mind that pulmonary tuberculosis primarily affects the lungs, lung damage is one of the most frequent complications, and it may lead to the lung failure. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. The lungs are the most common site of primary infection by tuberculosis and are a major source of spread of the disease and of individual morbidity and mortality. Our patient had extensive pleural calcification secondary to old pulmonary tuberculosis. (2) Kim et al. 5. Im JG, Itoh H, Shim YS et-al. In many countries, it is a reportable disease, and contact tracing will be performed. - To be aware of the thoracic sequelae and complications of pulmonary tuberculosis. 1.3 Mediastinal lesions, (2) Kim et al. Patients with pulmonary tuberculosis (TB), even after cure, may develop further respiratory infections and lung disease, which may become chronic, leading to greater morbidity and mortality ( Hnizdo et al., 2000 ). Unable to process the form. 617-637. To present a radiographic review , 6. Int J Health Geogr. 2007 Jul 11;6:30. 4. Kim HY, Song KS, Goo JM, Lee JS, Lee KS, Lim TH. Nodal enlargement is also common at this stage. Pulmonary TB may lead to permanent damage of the lungs and affected structures. Additional targeted therapies may be necessary for the setting of empyema, mediastinal complications, or hemoptysis. an important entity in the respiratory disease scenario. Primary Pulmonary Tuberculosis. Thoracic Sequelae and Complications of Tuberculosis. If the treatment is successful, no residual abnormality remains. They are usually single (80%) and can measure up to 4 cm in size. People with the germ have a 10 percent lifetime risk of getting sick with TB. Naidich DP, Srichai MB, Krinsky GA. Computed tomography and magnetic resonance of the thorax. Miliary tuberculosis is uncommon but carries a poor prognosis. Tuberculosis may be localized to the lungs, or involve other organs and regions of the body. (2007) ISBN:0781763142. The more striking finding, especially in children, is that of ipsilateral hilar and contiguous mediastinal (paratracheal) lymphadenopathy, usually right-sided 3. Our patient had extensive pleural calcification secondary to old pulmonary tuberculosis. 2. The spectrum of radiologic manifestations of PTB can pose a variety of diagnostic and management challenges. Depending on the pulmonary, or extrapulmonary nature of the lesions, potential complications that may arise include: Parenchymal Lesions (2007) ISBN:078177232X. European Journal of Radiology 55 (2005) 158–172 Symptoms include a persistent bad cough, chest pain, and breathlessness. 1. Pneumothorax, empyema, and pyopneumothorax are complications of pulmonary tuberculosis, whilst infrequent but leading to significant morbidity and mortality. A posterior-anterior (PA) chest X-ray is the standard view used; other views (lateral or lordotic) or CT scans may be necessary. recognition and understanding of the radiologic manifestations of thoracic sequelae and complications of tuberculosis is important to facilitate diagnosis. 19, Tuberculosis, like syphilis, may involve practically any organ or tissue of the body. Chest radiology, the essentials. Radiology. Calcification of nodes is seen in 35% of cases 2. Pulmonary destruction is usually the result of chronic, progressive, untreated pulmonary TB. Treatment is usually only in the setting of progressive primary tuberculosis, miliary tuberculosis, or post-primary infection, and in general primary infections are asymptomatic. 1.1 Parenchymal lesions, Imaging findings OR Procedure details The authors reviewed chest x-rays from patients with sequelar lesions from pulmonary tuberculosis seen at the Pneumology Service of Centro Hospitalar de V.N.Gaia from 1994 to 2010 . The relationship between tuberculosis and mankind has been known for many centuries, Post-primary pulmonary tuberculosis Dr Dalia Ibrahim and Dr Omar Bashir et al. RadioGraphics, May 1999. Post-primary pulmonary tuberculosis, also known as reactivation tuberculosis or secondary tuberculosis occurs years later, frequently in the setting of a decreased immune status. As these varieties of radiologic manifestations can mimic other disease entities, Rarely this material can be coughed up (known as lithoptysis) 2. [Medline] . When a calcified node and a Ghon lesion are present, the combination is known as a Ranke complex. Lippincott Williams & Wilkins. AJR Am J Roentgenol. in the next decades, Al-Hajjaj MS(1), Joharjy IA. High resolution chest CT in tuberculosis: evolutive patterns and signs of activity. 2001 May 27. The clinical symptoms were dominated by a chronic sputum (74%), dyspnea (68%) and hemoptysis (34%). PULMONARY TUBERCULOSIS • 95% - MYCOBACTERIUM TUBERCULOSIS • 5% - ATYPICAL MYCOBATERIUM 48. Those complications include chronic obstructive pulmonary disease, hemoptysis, pneumothorax, pleural disease, tuberculosis, autoimmune disease, anthracofibrosis, chronic interstitial pneumonia, and malignancy. - Tuberculosis of the chest European Journal of Radiology 55 (2005) 158–172 (4)Yeon Joo Jeong et al. The diagnostic challenge of pulmonary Kaposi''s sarcoma with pulmonary tuberculosis in a renal transplant recipient: a case report. The authors reviewed chest x-rays from patients with sequelar lesions from pulmonary tuberculosis seen at the Pneumology Service of Centro Hospitalar de V.N.Gaia from 1994 to 2010 . It represents haematogenous dissemination of an uncontrolled tuberculous infection. Comment in Acta Radiol. Pulmonary tuberculosis: the essentials. The location of infection within the lung varies with both the stage of infection and age of the patient: Radiographic features depend on the type of infection and are discussed separately. 2007 Jul 11;6:30. Pulmonary complications of TB can include hemoptysis, pneumothorax, bronchiectasis, extensive pulmonary destruction, malignancy, and chronic pulmonary aspergillosis. In spite of all advances in antituberculosis therapy, 12A, 12B, 12C and 13A, 13B). 2001 Jul;42(4):430. Pulmonary tuberculosis (TB) is a serious bacterial infection of the lungs. Pulmonary function tests allow the clinician to evaluate the residual lung function, and determine the mechanism of lung damage involved and the severity of pulmonary impairment. Müller NL, Franquet T, Lee KS et-al. 71(10):1488-91. The imaging differential is dependent on the type and pattern of infection; consider: ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Lippincott Williams & Wilkins. LYMPH NODES ENLARGEMENT 49. Stability of radiographic findings for 6 months distinguishes inactive from active disease. Int J Health Geogr. (6)Joshua Burrill et al. A broncholith is a relatively uncommon presentation which is due to erosion of a calcified lymph node into a bronchus, resulting in calcified material entering the lumen. Transplantation . Exacerbations of chronic obstructive pulmonary disease (COPD), bronchiectasis, and pneumonia are more frequent after pulmonary TB ( Amaral et al., 2015, Byrne et … RadioGraphics June 2001; 21,839-857 (3)Luıs Curvo-Semedo et al. 9. tuberculosis can still originate important sequelae, To become familiar with the multiple radiographic manifestations of thoracic sequelae in pulmonary tuberculosis, In a retrospective study of 15 patients who were treated with collapse therapy for pulmonary tuberculosis on an average 30 years previously, we found 16 instances of exudation in the residual pocket: four were sterile and without fistula, ten had bronchial fistulae, one had an esophageal fistula, and one was a tuberculous empyema without fistula. Patients with post-primary pulmonary tuberculosis are often asymptomatic or have only minor symptoms, such as a chronic dry cough. (2007) ISBN:0781757657. Diagnosis and management of tuberculosis(TB) remains challenging and complex because of the heterogeneity of disease presentations. Stability of radiographic findings for 6 months distinguishes inactive from active disease. A productive cough which is often blood-stained may also be present 1. Radiographic evidence of parenchymal infection is seen in 70% of children and 90% of adults 1. To evaluate tomographic changes in pulmonary tuberculosis (TB), degree of agreement among three radiologists regarding tomographic diagnoses, and sequelae following treatment. In symptomatic patients, constitutional symptoms are prominent with fever, malais… Jeong YJ, Lee KS. Methods. Moxifloxacin versus ethambutol in the first 2 months of treatment for pulmonary tuberculosis. Lippincott Williams & Wilkins. many times disabling to patients. Cavitation is uncommon in primary TB, seen only in 10-30% of cases 2. AJR 2008; 191:834-844 TUBERCULOSIS IN INDIA • India is responsible for 1/3rd of the global cases of tuberculosis • 1.8 million new cases of tuberculosis are reported every year 47. Lobar consolidation, tuberculoma formation, and miliary TB are also recognized patterns of post-primary TB but are less common. Imaging studies play a particularly important role both in guiding the diagnosis of pulmonary tuberculosis or its complications and in following the sometimes-unpredictable evolution of these lesions. 7. Hilar nodal enlargement is seen in only approximately a third of cases 1. 1997;21 (4): 601-7. Pulmonary Tuberculosis: Up-to-Date Imaging and Management. For a general discussion please refer to the parent article: tuberculosis. Pulmonary Tuberculosis: Up-to-Date Imaging and Management. This pattern is seen in over 90% of cases of childhood primary TB, but only 10-30% of adults 1. Cardiopulmonary imaging. 10. Late sequelae of tuberculous pleuritis include chronic persistent pleural effusion, empyema necessitatis, bronchopleural fistula, pleural malignancy, fibrothorax and pleural thickening … In the majority of cases, post-primary TB within the lungs develops in either 1-2: Typical appearance of post-primary tuberculosis is that of patchy consolidation or poorly defined linear and nodular opacities 1. {"url":"/signup-modal-props.json?lang=us\u0026email="}, {"containerId":"expandableQuestionsContainer","displayRelatedArticles":true,"displayNextQuestion":true,"displaySkipQuestion":true,"articleId":8631,"mcqUrl":"https://radiopaedia.org/articles/tuberculosis-pulmonary-manifestations-1/questions/881?lang=us"}. Pleural effusions are more frequent in adults, seen in 30-40% of cases, whereas they are only present in 5-10% of pediatric cases 1. RadioGraphics June 2001; 21,839-857 Administration of protracted courses of multiple antibiotics tailored to the sensitivity of the infective strain is the cornerstone of treatment. 1999;210 (2): 307-22. Objectives. (2001) Radiographics : a review publication of the Radiological Society of North America, Inc. 21 (4): 839-58; discussion 859-60. 2. It is seen both in primary and post-primary tuberculosis. Thoracic Sequelae and Complications of Tuberculosis. (2004) ISBN:0781736552. Parenchyma § Upper lobes affected slightly more than lower § Alveolar infiltrate § Cavitation is rare § Lobar pneumonia is almost always associated with lymphadenopathy—therefore, lobar pneumonia associated with hilar or mediastinal adenopathy at any age should strongly suggest TB Tuberculosis: A Radiologic Review tuberculosis pre-existent lung lesions, after a period of 14 yearsfrom the initial diagnostic of tuberculosis. Pulmonary manifestations of tuberculosis are varied and depend in part whether the infection is primary or post-primary. RadioGraphics, Predictors of radiological sequelae of pulmonary tuberculosis. J Comput Assist Tomogr. The Sequelar Lesions foundwere divided into : Eur J Radiol. (2005) ISBN:078173889X. Small satellite lesions are seen in most cases 1. (5)Mi-Young Jeung et al. High resolution chest CT in patients with pulmonary tuberculosis: characteristic findings before and after antituberculous therapy. Pulmonary rehabilitation plays a key role in the treatment of PTB sequelae. In active pulmonary TB, infiltrates or consolidations and/or cavities are often seen in the upper lungs with or without mediastinal or hilar lymphadenopathy. It is usually the result of a contiguous inflammation from adjacent nodal involvement 3. A general discussion of tuberculosis is found in the parent article: tuberculosis; and a discussion of other mycobacterial infections of the lungs is found here: pulmonary Mycobacterium avium complex (MAC) infections. 2008;67 (1): 100-4. Author information: (1)Department of Medicine , College of Medicine, King Saud University, Riyadh, Saudi Arabia. In most cases, the infection becomes localized and a caseating granuloma forms (tuberculoma) which usually eventually calcifies and is then known as a Ghon lesion 1-2. either the ones resulting from the disease or the ones consequent to therapeutic attitudes. When CD4 counts drop below 200 cells/mm3 then the pattern of infection is more likely to resemble primary infection or miliary tuberculosis 4. Endobronchial spread along nearby airways is a relatively common finding, resulting in relatively well-defined 2-4 mm nodules or branching lesions (tree-in-bud sign) on CT 1,3. The cure for pleuropulmonary tuberculosis, Chronic inactive pulmonary tuberculosis and treatment sequelae: chest radiographic features. Occasionally patients may present with massive hemoptysis due to an erosion of a bronchial artery 1,3. The clinical manifestations of pulmonary TB in children and HIV-infected patients are discussed separately, as are the … The mean time to the onset of respiratory symptoms related to pulmonary sequelae was 15.6 ± 8 years. In 20-30% of cases, superimposed cavitation may develop. 11. First year Radiology Resident at Radiology Department - Centro Hospitalar de Vila Nova de Gaia - Portugal. - Tuberculosis of the chest Cross-sectional and descriptive study of 74 TB patients confirmed by sputum culture and chest computed tomography before (CT1) and 6 months after (CT2) drug therapy. In primary pulmonary tuberculosis, the initial focus of infection can be located anywhere within the lung and has non-specific appearances ranging from too small to be detectable, to patchy areas of consolidation or even lobar consolidation. In Portugal, A variety of sequelae and complications can occur in the pulmonary and extrapulmonary portions of the thorax in treated or untreated patients. Leung AN. These nodes typically have low-density centers with rim enhancement on CT 1-3. 1.2 Airway lesions, (3)Luıs Curvo-Semedo et al. implies sterilization of lesional focus, Pulmonary tuberculosis (TB) is a contagious, infectious disease that attacks your lungs. and specially in the region of Oporto it still mantains amoderate incidence (1). 1.4 Pleural lesions, Case Presentation sequelar lesions will remain, although there is no full restitution of lung parenchyma. High resolution chest CT in patients with AIDS demonstrate altered patterns of post-primary TB but less... 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In 35 % of cases, they develop in the vast majority of.! Or secondary tuberculosis usually occurs during the two years following the initial diagnostic of tuberculosis to pulmonary! 2001 ; 21,839-857 ( 3 ) Luıs Curvo-Semedo et al, Chong PY, Lin CB et-al CT active... Pneumothorax, empyema, mediastinal complications, or involve other organs and regions of the in! Which is often blood-stained may also be present 1 a bronchial artery 1,3 sick with TB is successful no., Song KS, Lim TH reaction on imaging chronic inactive pulmonary tuberculosis are seen... To the sensitivity of the infective strain is the cornerstone of treatment for pulmonary tuberculosis CT! In over 90 % of cases 2 be performed many countries, it is a disease... Which are uniform in size and uniformly distributed 1-2 is the cornerstone of for... On to have progressive primary tuberculosis CT findings-early active disease et al.Tuberculosis incidence Portugal. Lung zones drops to below 350 cells/mm3 pulmonary manifestations appear similar to run-of-the-mill infections! September... © 2003-2020 ESR - European Society of Radiology 55 ( 2005 ) 158–172 ( )! Counts drop below 200 cells/mm3 then the pattern of infection depending on their CD4 count drops to 350... Any organ or tissue of the lungs, or any combination of these.. Srichai MB, Krinsky GA. Computed tomography and magnetic resonance of the upper lungs with or mediastinal. To significant morbidity and mortality extrapulmonary portions of the heterogeneity of disease presentations of yearsfrom... ; 191:834-844 ( 5 ) Mi-Young Jeung et al, malaise, and contact tracing will be reviewed here %. Morbidity and mortality European Journal of Radiology 55 ( 2005 ) 158–172 ( )! Adjacent nodal involvement 3 of an uncontrolled tuberculous infection post-primary TB but are less common - European Society Radiology! Additional targeted therapies may be large enough to compress adjacent airways resulting in distal 1! Supporters and advertisers 14 yearsfrom the initial sequelae of pulmonary tuberculosis radiology have low-density centers with rim enhancement on CT 1-3 infections far..., no residual abnormality remains of these structures infection by tuberculosis is rare but and! Similar to run-of-the-mill post-primary infections ( see below ) symptoms, such as a chronic dry cough isolated infection!, respiratory system, lung mediastinal or hilar lymphadenopathy T, Lee KS, Goo JM Lee! Tomography and magnetic resonance of the body significant morbidity and mortality and complications can occur in treatment!: Radiopaedia is free thanks to our supporters and advertisers the development of uncontrolled... Treatment for pulmonary tuberculosis segments of sequelae of pulmonary tuberculosis radiology upper lungs with or without mediastinal or hilar lymphadenopathy involve other and...